Medical Formulas Based on Sex Support Biology as the Basis for Gender


Published August 9, 2022

American Council on Science and Health

Recent demands by mainstream transgender communities insist on Americans conforming to respecting the words people use to describe themselves, including during physician visits and hospital admissions. Transgender people may use many different terms to describe their genders, but the problem with that is that pharmacology doesn’t see it that way.  Since gender is determined at conception, it doesn’t matter how much synthetic estrogen or testosterone one pumps into their body; their biological gender remains. 

Physicians, nutritionists, pharmacologists, and pharmacists routinely use dozens of algorithms requiring the specification of male or female to calculate the accurate dosages of the over 20,000 FDA-approved drugs. 

For example, multiple published, peer-reviewed studies have shown that certain drugs, like benzodiazepines, may be cleared more quickly in women than men.  CYP3A4 is a human liver enzyme responsible for the metabolism of over 50% of therapeutic drugs and 70–80% of all drugs in current clinical useWomen have 20-40% times the CYP3A4 activity of men, detailing the noteworthy metabolic difference between men and women. 

In all, definitive gender-related metabolism is a critical consideration in establishing doses for some of the most common drugs in every major classification, including psychiatric, antimicrobials, anti-inflammatories, pain control, cardiovascular, immunosuppressive, antiviral, cholesterol-lowering, cancer, asthma, in addition to others. 

A complete, hyperlinked, and fully referenced list of sex-specific pharmacology and medical equations independent of this article may be viewed as a standalone addendum here. 

David Gortler, Pharm.D. FCCP is a Fellow at the Ethics and Public Policy Center whose work focuses on FDA oversight and accountability. Dr. Gortler is a pharmacologist and pharmacist and a Yale-trained bench research scientist in molecular biology with a subspecialty in the field of vascular medicine.  He was a professor of pharmacology and biotechnology at the Yale University School of Medicine, where he also served at Yale’s Center for Bioethics, and was an FDA Medical Officer who was later appointed by the White House to serve on the FDA’s Senior Executive Leadership Team as senior advisor to the FDA Commissioner.

Photo by Tim Mossholder on Unsplash


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